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Titel: Retinal Vascular Occlusion after COVID-19 Vaccination : More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study
VerfasserIn: Feltgen, Nicolas
Ach, Thomas
Ziemssen, Focke
Quante, Carolin Sophie
Gross, Oliver
Abdin, Alaa Din
Aisenbrey, Sabine
Bartram, Martin C.
Blum, Marcus
Brockmann, Claudia
Dithmar, Stefan
Friedrichs, Wilko
Guthoff, Rainer
Hattenbach, Lars-Olof
Herrlinger, Klaus R.
Kaskel-Paul, Susanne
Khoramnia, Ramin
Klaas, Julian E.
Krohne, Tim U.
Lommatzsch, Albrecht
Lueken, Sabine
Maier, Mathias
Nassri, Lina
Nguyen-Dang, Thien A.
Radeck, Viola
Rau, Saskia
Roider, Johann
Sandner, Dirk
Schmalenberger, Laura
Schmidtmann, Irene
Schubert, Florian
Siegel, Helena
Spitzer, Martin S.
Stahl, Andreas
Stingl, Julia V.
Treumer, Felix
Viestenz, Arne
Wachtlin, Joachim
Wolf, Armin
Zimmermann, Julian
Schargus, Marc
Schuster, Alexander K.
Sprache: Englisch
Titel: Journal of Clinical Medicine
Bandnummer: 11
Heft: 17
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: retinal vein occlusion
retinal artery occlusion
anterior ischaemic optic neuropathy
infection
vaccination
SARS-CoV-2
COVID-19
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD). Methods: In this multicentre study, data from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June–31 July 2021) according to a defined protocol. The relation to any previous vaccination was documented for the consecutive case series. Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case– control study using age- and sex-matched controls from the general population (study participants from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was conducted. Results: Four hundred and twenty-one subjects presenting during the index period (61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO, fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our case–control analysis integrating population-based data from the GHS yielded no evidence of an increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60–1.45, p = 0.75) in connection with a vaccination within a 4-week window. Conclusions: To date, there has been no evidence of any association between SARS-CoV-2 vaccination and a higher RVOD risk.
DOI der Erstveröffentlichung: 10.3390/jcm11175101
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-371778
hdl:20.500.11880/33732
http://dx.doi.org/10.22028/D291-37177
ISSN: 2077-0383
Datum des Eintrags: 12-Sep-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/jcm11175101/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Augenheilkunde
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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