| Dokumenttyp | Erscheinungsjahr | Titel | Autoren | Herausgeber |
|---|
| article | 2024 | Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents | Khalifa, Hend; Rasheed, Sari Shawki; Haupenthal, Jörg; Herrmann, Jennifer; Mandour, Yasmine M.; Abadi, Ashraf H.; Engel, Matthias; Müller, Rolf; Hirsch, Anna; Abdel-Halim, Mohammad; Hamed, Mostafa M. | |
| article | 2024 | Correction: Fries et al. Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin A Using a Staphylococcus aureus Infection Model in Zebrafish Embryos. Int. J. Mol. Sci. 2023, 24, 12791 | Fries, Franziska; Kany, Andreas M.; Rasheed, Sari Shawki; Hirsch, Anna; Müller, Rolf; Herrmann, Jennifer | |
| article | 2024 | Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery | Afanasenko, Anastasiia M.; Wu, Xianyuan; De Santi, Alessandra; Elgaher, Walid A. M.; Kany, Andreas M.; Shafiei, Roya; Schulze, Marie-Sophie; Schulz, Thomas F.; Haupenthal, Jörg; Hirsch, Anna; Barta, Katalin | |
| article | 2024 | Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT | Exapicheidou, Ioulia Antonia; Shams, Atanaz; Ibrahim, Hamza; Tsarenko, Aleksei; Backenköhler, Michael; Hamed, Mostafa M.; Diamanti, Eleonora; Volkamer, Andrea; Slotboom, Dirk J.; Hirsch, Anna K. H. | |
| article | 2024 | Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis | Stella, Justin; Abdelaal, Maryam Ayman Mohamed Ezzat; Kamal, Mohamed Ashraf Mostafa; Shehu, Kristela; Alhayek, Alaa; Haupenthal, Jörg; Hirsch, Anna K.; Schneider, Marc | |
| article | 2024 | Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs) | Haupenthal, Jörg; Rafehi, Muhammad; Kany, Andreas M.; Lespine, Anne; Stefan, Katja; Hirsch, Anna K. H.; Stefan, Sven Marcel | |
| article | 2024 | High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum | Johannsen, Sandra; Gierse, Robin M.; Krüger, Arne; Edwards, Rachel L.; Nanna, Vittoria; Fontana, Anna; Zhu, Di; Masini, Tiziana; de Carvalho, Lais Pessanha; Poizat, Mael; Kieftenbelt, Bart; Hodge, Dana M.; Alvarez, Sophie; Bunt, Daan; Lacour, Antoine; Shams, Atanaz; Meissner, Kamila Anna; de Souza, Edmarcia Elisa; Dröge, Melloney; van Vliet, Bernard; den Hartog, Jack; Hutter, Michael C.; Held, Jana; Odom John, Audrey R.; Wrenger, Carsten; Hirsch, Anna | |
| article | 2023 | Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors | Ropponen, Henni-Karoliina; Diamanti, Eleonora; Johannsen, Sandra; Illarionov, Boris; Hamid, Rawia Abdulazeem Ahmed; Jaki, Miriam; Sass, Peter; Fischer, Markus; Haupenthal, Jörg; Hirsch, Anna | |
| article | 2023 | Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor | Berwanger, Aylin; Stein, Saskia C.; Kany, Andreas M.; Gartner, Melissa; Loretz, Brigitta; Lehr, Claus-Michael; Hirsch, Anna; Schulz, Thomas F.; Empting, Martin | |
| article | 2023 | Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase | Xie, Feng; Kiefer, Alexander F.; Hirsch, Anna; Kalinina, Olga V.; Fu, Chengzhang; Müller, Rolf | |
| article | 2023 | Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos | Fries, Franziska; Kany, Andreas M.; Rasheed, Sari Shawki; Hirsch, Anna; Müller, Rolf; Herrmann, Jennifer | |
| article | 2023 | Revision of the Absolute Configurations of Chelocardin and Amidochelocardin | Sikandar, Asfandyar; Popoff, Alexander; Jumde, Ravindra P.; Mándi, Attila; Kaur, Amninder; Elgaher, Walid A. M.; Rosenberger, Lara Annette; Hüttel, Stephan; Jansen, Rolf; Hunter, Maja; Köhnke, Jesko; Hirsch, Anna; Kurtán, Tibor; Müller, Rolf | |
| article | 2023 | Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections | Konstantinović, Jelena; Kany, Andreas M.; Alhayek, Alaa; Abdelsamie, Ahmed S.; Sikandar, Asfandyar; Voos, Katrin; Yiwen, Yao; Andreas, Anastasia; Shafiei, Roya; Loretz, Brigitta; Schönauer, Esther; Bals, Robert; Brandstetter, Hans; Hartmann, Rolf W.; Ducho, Christian; Lehr, Claus-Michael; Beißwenger, Christoph; Müller, Rolf; Rox, Katharina; Haupenthal, Jörg; Hirsch, Anna | |
| article | 2023 | Identification of HuR-RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization | Volpe, Serena Della; Listro, Roberta; Ambrosio, Francesca Alessandra; Garbagnoli, Martina; Linciano, Pasquale; Rossi, Daniela; Costa, Giosuè; Alcaro, Stefano; Vasile, Francesca; Hirsch, Anna; Collina, Simona | |
| article | 2023 | New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development | Seyfert, Carsten E.; Müller, Alison V.; Walsh, Danica J.; Birkelbach, Joy; Kany, Andreas M.; Porten, Christoph; Yuan, Biao; Krug, Daniel; Herrmann, Jennifer; Marlovits, Thomas C.; Hirsch, Anna; Müller, Rolf | |
| article | 2023 | Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape | Lee, Sangeun; Nasr, Sarah Samir Mahmoud; Rasheed, Sari Shawki; Liu, Yun; Hartwig, Olga; Kaya, Cansu; Boese, Annette; Koch, Marcus; Herrmann, Jennifer; Müller, Rolf; Loretz, Brigitta; Buhler, Eric; Hirsch, Anna; Lehr, Claus-Michael | |
| article | 2023 | 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding | Hamid, Rawia; Adam, Sebastian; Lacour, Antoine; Monjas, Leticia; Köhnke, Jesko; Hirsch, Anna K. H. | |
| article | 2023 | pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA | Liu, Yun; Ashmawy, Salma; Latta, Lorenz; Weiss, Agnes-Valencia; Kiefer, Alexander F.; Nasr, Sarah; Loretz, Brigitta; Hirsch, Anna K. H.; Lee, Sangeun; Lehr, Claus-Michael | |
| article | 2022 | First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization | Gierse, Robin M.; Oerlemans, Rick; Reddem, Eswar R.; Gawriljuk, Victor O.; Alhayek, Alaa; Baitinger, Dominik; Jakobi, Harald; Laber, Bernd; Lange, Gudrun; Hirsch, Anna K. H.; Groves, Matthew R. | |
| article | 2022 | An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay | Bousis, Spyridon; Winkler, Steffen; Haupenthal, Jörg; Fulco, Francesco; Diamanti, Eleonora; Hirsch, Anna K. H. | |
| article | 2022 | Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters | Kiefer, Alexander F.; Bousis, Spyridon; Hamed, Mostafa M.; Diamanti, Eleonora; Haupenthal, Jörg; Hirsch, Anna K. H. | |
| article | 2022 | Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors | Hamdy, Jehad; Emadeldin, Nouran; Hamed, Mostafa M.; Frakolaki, Efseveia; Katsamakas, Sotirios; Vassilaki, Niki; Zoidis, Grigoris; Hirsch, Anna K. H.; Abdel-Halim, Mohammad; Abadi, Ashraf H. | |
| article | 2022 | Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism | Chen, F.; Elgaher, W. A.M.; Winterhoff, M.; Büssow, K.; Waqas, F. H.; Graner, E.; Pires-Afonso, Y.; Casares Perez, L.; de la Vega, L.; Sahini, N.; Czichon, L.; Zobl, W.; Zillinger, T.; Shehata, M.; Pleschka, S.; Bähre, H.; Falk, C.; Michelucci, A.; Schuchardt, S.; Blankenfeldt, W.; Hirsch, A. K. H.; Pessler, F. | |
| article | 2022 | Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa | Kaya, Cansu; Walter, Isabell; Alhayek, Alaa; Shafiei, Roya; Jézéquel, Gwenaëlle; Andreas, Anastasia; Konstantinović, Jelena; Schönauer, Esther; Sikandar, Asfandyar; Haupenthal, Jörg; Müller, Rolf; Brandstetter, Hans; Hartmann, Rolf W.; Hirsch, Anna K. H. | |
| article | 2022 | N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases | Kaya, Cansu; Konstantinović, Jelena; Kany, Andreas M.; Andreas, Anastasia; Kramer, Jan S.; Brunst, Steffen; Weizel, Lilia; Rotter, Marco J.; Frank, Denia; Yahiaoui, Samir; Müller, Rolf; Hartmann, Rolf W.; Haupenthal, Jörg; Proschak, Ewgenij; Wichelhaus, Thomas A.; Hirsch, Anna K. H. | |
| article | 2022 | Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance | Rosenberger, Lara Annette; Jenniches, Judith; von Essen, Carolina; Khutia, Anupam; Kühn, Clemens; Marx, Andreas; Georgi, Katrin; Hirsch, Anna K. H.; Hartmann, Rolf W.; Badolo, Lassina | |
| article | 2022 | Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections | Alhayek, Alaa; Khan, Essak S.; Schönauer, Esther; Däinghaus, Tobias; Shafiei, Roya; Voos, Katrin; Han, Mitchell K. L.; Ducho, Christian; Posselt, Gernot; Wessler, Silja; Brandstetter, Hans; Haupenthal, Jörg; del Campo Bécares, Aránzazu; Hirsch, Anna K. H. | |
| Other | 2022 | N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH | Voos, Katrin; Yahiaoui, Samir; Konstantinović, Jelena; Schönauer, Esther; Alhayek, Alaa; Sikandar, Asfandyar; Si Chaib, Khadidja; Ramspoth, Tizian; Rox, Katharina; Haupenthal, Jörg; Köhnke, Jesko; Brandstetter, Hans; Ducho, Christian; Hirsch, Anna | |
| article | 2022 | Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening | Zhu, Di; Johannsen, Sandra; Masini, Tiziana; Simonin, Céline; Haupenthal, Jörg; Illarionov, Boris; Andreas, Anastasia; Awale, Mahendra; Gierse, Robin M.; van der Laan, Tridia; van der Vlag, Ramon; Nasti, Rita; Poizat, Mael; Buhler, Eric; Reiling, Norbert; Müller, Rolf; Fischer, Markus; Reymond, Jean-Louis; Hirsch, Anna K. H. | |
| article | 2022 | Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry | Bagnolini, Greta; Balboni, Beatrice; Schipani, Fabrizio; Gioia, Dario; Veronesi, Marina; De Franco, Francesca; Kaya, Cansu; Jumde, Ravindra P.; Ortega, Jose Antonio; Girotto, Stefania; Hirsch, Anna; Roberti, Marinella; Cavalli, Andrea | |
| article | 2021 | N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa | Yahiaoui, Samir; Voos, Katrin; Haupenthal, Jörg; Wichelhaus, Thomas A.; Frank, Denia; Weizel, Lilia; Rotter, Marco; Brunst, Steffen; Kramer, Jan S.; Proschak, Ewgenij; Ducho, Christian; Hirsch, Anna K. H. | |
| article | 2021 | Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor | Drost, Menka; Diamanti, Eleonora; Fuhrmann, Kathrin; Goes, Adriely; Shams, Atanaz; Haupenthal, Jörg; Koch, Marcus; Hirsch, Anna K. H.; Fuhrmann, Gregor | |
| article | 2021 | Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier | Abdallah, Mennatallah; Hamed, Mostafa M.; Frakolaki, Efseveia; Katsamakas, Sotirios; Vassilaki, Niki; Bartenschlager, Ralf; Zoidis, Grigoris; Hirsch, Anna K. H.; Abdel-Halim, Mohammad; Abadi, Ashraf H. | |
| article | 2021 | Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class | Diamanti, Eleonora; Hamed, Mostafa M.; Lacour, Antoine; Bravo, Patricia; Illarionov, Boris; Fischer, Markus; Rottmann, Matthias; Witschel, Matthias; Hirsch, Anna K. H. | |
| article | 2021 | Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization | Della Volpe, S.; Linciano, P.; Listro, R.; Tumminelli, E.; Amadio, M.; Bonomo, I.; Elgaher, W. A. M.; Adam, S.; Hirsch, A. K. H.; Boeckler, F. M.; Vasile, F.; Rossi, D.; Collina, S. | |
| article | 2021 | Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties | Gierse, Robin M.; Reddem, Eswar R.; Alhayek, Alaa; Baitinger, Dominik; Zhoor, Hamid; Jakobi, Harald; Laber, Bernd; Lange, Gudrun; Hirsch, Anna K. H.; Groves, Matthew R. | |
| article | 2021 | Hit-optimization using target-directed dynamic combinatorial chemistry : development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase | Jumde, Ravindra P.; Guardigni, Melissa; Gierse, Robin M.; Alhayek, Alaa; Zhu, Di; Hamid, Zhoor; Johannsen, Sandra; Elgaher, Walid A. M.; Neusens, Philipp J.; Nehls, Christian; Haupenthal, Jörg; Reiling, Norbert; Hirsch, Anna K. H. | |
| article | 2021 | Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors | Kaya, Cansu; Walter, Isabell; Yahiaoui, Samir; Sikandar, Asfandyar; Alhayek, Alaa; Konstantinović, Jelena; Kany, Andreas M.; Haupenthal, Jörg; Köhnke, Jesko; Hartmann, Rolf W.; Hirsch, Anna K. H. | |
| article | 2021 | Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor | Khairat, Sarah H. M.; Omar, Mohamed A.; Ragab, Fatma A. F.; Roy, Sonam; Turab Naqvi, Ahmad A.; Ahmed, Ahmed S.; Hirsch, Anna K. H.; Galal, Shadia A.; Hassan, Md Imtaiyaz; El Diwani, Hoda I. | |
| article | 2021 | Unveiling Adatoms in On-Surface Reactions: Combining Scanning Probe Microscopy with van't Hoff Plots | Moreno-López, Juan Carlos; Pérez Paz, Alejandro; Gottardi, Stefano; Solianyk, Leonid; Li, Jun; Monjas, Leticia; Hirsch, Anna K. H.; Mowbray, Duncan John; Stöhr, Meike | |
| article | 2021 | Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity | Ropponen, Henni-Karoliina; Bader, Chantal D.; Diamanti, Eleonora; Illarionov, Boris; Rottmann, Matthias; Fischer, Markus; Witschel, Matthias; Müller, Rolf; Hirsch, Anna K. H. | |
| article | 2021 | Assessment of the rules related to gaining activity against Gram-negative bacteria | Ropponen, Henni-Karoliina; Diamanti, Eleonora; Siemens, Alexandra; Illarionov, Boris; Haupenthal, Jörg; Fischer, Markus; Rottmann, Matthias; Witschel, Matthias; Hirsch, Anna K. H. | |
| article | 2021 | Crystalline sponge affinity screening : A fast tool for soaking condition optimization without the need of X-ray diffraction analysis | Rosenberger, Lara; von Essen, Carolina; Khutia, Anupam; Kühn, Clemens; Georgi, Katrin; Hirsch, Anna K. H.; Hartmann, Rolf W.; Badolo, Lassina | |
| article | 2021 | Phosphonate as a Stable Zinc-Binding Group for "Pathoblocker" Inhibitors of Clostridial Collagenase H (ColH) | Voos, Katrin; Schönauer, Esther; Alhayek, Alaa; Haupenthal, Jörg; Andreas, Anastasia; Müller, Rolf; Hartmann, Rolf W.; Brandstetter, Hans; Hirsch, Anna K. H.; Ducho, Christian | |
| article | 2021 | "Clicking" fragment leads to novel dual-binding cholinesterase inhibitors | Molęda, Zuzanna; Zawadzka, Anna; Czarnocki, Zbigniew; Monjas, Leticia; Hirsch, Anna K.H.; Budzianowski, Armand; Maurin, Jan K. | |
| Other | 2021 | Targeting the energy-coupling factor (ECF) transporters : identification of new tool compounds | Diamanti, Eleonora; Setyawati, Inda; Bousis, Spyridon; Souza, Paulo C. T.; Mojas, Leticia; Swier, Lotteke; Haupenthal, Jörg; Gibson, Paddy; Volz, Carsten; Stanek, Weronika; Jaeger, Manuel; Herrmann, Jennifer; Marrink, Siewert; Veening, Jan-willem; Müller, Rolf; Slotboom, Dirk J.; Hirsch, Anna K.H. | |
| article | 2021 | A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms | Schütz, Christian; Ho, Duy-Khiet; Hamed, Mostafa Mohamed; Abdelsamie, Ahmed Saad; Röhrig, Teresa; Herr, Christian; Kany, Andreas Martin; Rox, Katharina; Schmelz, Stefan; Siebenbürger, Lorenz; Wirth, Marius; Börger, Carsten; Yahiaoui, Samir; Bals, Robert; Scrima, Andrea; Blankenfeldt, Wulf; Horstmann, Justus Constantin; Christmann, Rebekka; Murgia, Xabier; Koch, Marcus; Berwanger, Aylin; Loretz, Brigitta; Hirsch, Anna Katharina Herta; Hartmann, Rolf Wolfgang; Lehr, Claus-Michael; Empting, Martin | |
| article | 2021 | Mastering the Gram-negative bacterial barrier : Chemical approaches to increase bacterial bioavailability of antibiotics | Ropponen, Henni-Karoliina; Richter, Robert; Hirsch, Anna K. H.; Lehr, Claus-Michael | |
| article | 2021 | Towards the sustainable discovery and development of new antibiotics | Miethke, Marcus; Pieroni, Marco; Weber, Tilmann; Brönstrup, Mark; Hammann, Peter; Halby, Ludovic; Arimondo, Paola B.; Glaser, Philippe; Aigle, Bertrand; Bode, Helge B.; Moreira, Rui; Li, Yanyan; Luzhetskyy, Andriy; Medema, Marnix H.; Pernodet, Jean-Luc; Stadler, Marc; Tormo, José Rubén; Genilloud, Olga; Truman, Andrew W.; Weissman, Kira J.; Takano, Eriko; Sabatini, Stefano; Stegmann, Evi; Brötz-Oesterhelt, Heike; Wohlleben, Wolfgang; Seemann, Myriam; Empting, Martin; Hirsch, Anna K. H.; Loretz, Brigitta; Lehr, Claus-Michael; Titz, Alexander; Herrmann, Jennifer; Jaeger, Timo; Alt, Silke; Hesterkamp, Thomas; Winterhalter, Mathias; Schiefer, Andrea; Pfarr, Kenneth; Hoerauf, Achim; Graz, Heather; Graz, Michael; Lindvall, Mika; Ramurthy, Savithri; Karlén, Anders; van Dongen, Maarten; Petkovic, Hrvoje; Keller, Andreas; Peyrane, Frédéric; Donadio, Stefano; Fraisse, Laurent; Piddock, Laura J. V.; Gilbert, Ian H.; Moser, Heinz E.; Müller, Rolf | |
| article | 2020 | BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application | Volpe, Serena Della; Listro, Roberta; Parafioriti, Michela; Di Giacomo, Marcello; Rossi, Daniela; Ambrosio, Francesca Alessandra; Costa, Giosuè; Alcaro, Stefano; Ortuso, Francesco; Hirsch, Anna; Vasile, Francesca; Collina, Simona | |
| article | 2020 | Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice | Haupenthal, Jörg; Kautz, Yannik; Elgaher, Walid A. M.; Pätzold, Linda; Röhrig, Teresa; Laschke, Matthias W.; Tschernig, Thomas; Hirsch, Anna K. H.; Molodtsov, Vadim; Murakami, Katsuhiko S.; Hartmann, Rolf W.; Bischoff, Markus | |
| article | 2020 | Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection | Murgia, Xabier; Kany, Andreas M.; Herr, Christian; Ho, Duy-Khiet; De Rossi, Chiara; Bals, Robert; Lehr, Claus-Michael; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin; Röhrig, Teresa | |
| article | 2020 | Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design | Axer, Alexander; Jumde, Ravindra P.; Adam, Sebastian; Faust, Andreas; Schäfers, Michael; Fobker, Manfred; Koehnke, Jesko; Hirsch, Anna K. H.; Gilmour, Ryan | |
| article | 2020 | Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes | Erdeljac, Nathalie; Thiehoff, Christian; Jumde, Ravindra P.; Daniliuc, Constantin G.; Höppner, Sandra; Faust, Andreas; Hirsch, Anna K. H.; Gilmour, Ryan | |
| article | 2020 | Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase | Hartman, Alwin M.; Jumde, Varsha R.; Elgaher, Walid A. M.; Te Poele, Evelien M.; Dijkhuizen, Lubbert; Hirsch, Anna K. H. | |
| article | 2020 | N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases | Konstantinović, Jelena; Yahiaoui, Samir; Alhayek, Alaa; Haupenthal, Jörg; Schönauer, Esther; Andreas, Anastasia; Kany, Andreas M.; Müller, Rolf; Koehnke, Jesko; Berger, Fabian K.; Bischoff, Markus; Hartmann, Rolf W.; Brandstetter, Hans; Hirsch, Anna K. H. | |
| article | 2020 | Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach | Konstantinidou, Markella; Magari, Francesca; Sutanto, Fandi; Haupenthal, Jörg; Jumde, Varsha R.; Ünver, M. Yagiz; Heine, Andreas; Camacho, Carlos Jamie; Hirsch, Anna K. H.; Klebe, Gerhard; Dömling, Alexander | |
| article | 2020 | 7-Hydroxycoumarins Are Affinity-Based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor | Xiao, Zhangping; Chen, Deng; Song, Shanshan; van der Vlag, Ramon; van der Wouden, Petra E.; van Merkerk, Ronald; Cool, Robbert H.; Hirsch, Anna K. H.; Melgert, Barbro N.; Quax, Wim J.; Poelarends, Gerrit J.; Dekker, Frank J. | |
| article | 2020 | A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate | Zahorska, Eva; Kuhaudomlarp, Sakonwan; Minervini, Saverio; Yousaf, Sultaan; Lepsik, Martin; Kinsinger, Thorsten; Hirsch, Anna K. H.; Imberty, Anne; Titz, Alexander | |
| article | 2020 | pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers | Lee, Sangeun; Kaya, Cansu; Jang, Hongje; Koch, Marcus; Loretz, Brigitta; Buhler, Eric; Lehr, Claus-Michael; Hirsch, Anna Katharina Herta | |
| article | 2020 | A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria | Richter, Robert; Kamal, Mohamed A. M.; García-Rivera, Mariel A.; Kaspar, Jerome; Junk, Maximilian; Elgaher, Walid A. M.; Srikakulam, Sanjay Kumar; Gress, Alexander; Beckmann, Anja; Grißmer, Alexander; Meier, Carola; Vielhaber, Michael; Kalinina, Olga; Hirsch, Anna K.H.; Hartmann, Rolf W.; Brönstrup, Mark; Schneider-Daum, Nicole; Lehr, Claus-Michael | |
| article | 2020 | Discovery of Small-Molecule Stabilizers of 14-3-3 Protein–Protein Interactions via Dynamic Combinatorial Chemistry | Hartman, Alwin M.; Elgaher, Walid A. M.; Hertrich, Nathalie; Andrei, Sebastian A.; Ottmann, Christian; Hirsch, Anna K. H. | |
| article | 2020 | Protein-Templated Hit Identification through an Ugi Four-Component Reaction | Mancini, Federica; Unver, M. Yagiz; Elgaher, Walid A. M.; Jumde, Varsha R.; Alhayek, Alaa; Lukat, Peer; Herrmann, Jennifer; Witte, Martin D.; Köck, Matthias; Blankenfeldt, Wulf; Müller, Rolf; Hirsch, Anna K. H. | |
| article | 2020 | Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I | Zisopoulou, Stavroula A.; Bousis, Spyridon; Haupenthal, Jörg; Herrmann, Jennifer; Müller, Rolf; Hirsch, Anna K. H.; Komiotis, Dimitri; Gallos, John K.; Stathakis, Christos I. | |
| Other | 2020 | François Diederich : In Memoriam | Hof, Fraser; Hirsch, Anna K. H. | |
| article | 2019 | Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists | Simhadri, Chakravarthi; Daze, Kevin D.; Douglas, Sarah F.; Milosevich, Natalia; Monjas, Leticia; Dev, Amarjot; Brown, Tyler M.; Hirsch, Anna; Wulff, Jeremy E.; Hof, Fraser | |
| article | 2019 | From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds | Elangovan, Saravanakumar; Afanasenko, Anastasiia; Haupenthal, Jörg; Sun, Zhuohua; Liu, Yongzhuang; Hirsch, Anna; Barta, Katalin | |
| Other | 2019 | Flotillin mediated membrane fluidity controls peptidoglycan synthesis and MreB movement | Zielińska, Aleksandra; Savietto, Abigail; de Sousa Borges, Anabela; Martinez, Denis; Berbon, Melanie; Roelofsen, Joël R.; Hartman, Alwin M.; de Boer, Rinse; van der Klei, Ida J.; Hirsch, Anna; Habenstein, Birgit; Bramkamp, Marc; Scheffers, Dirk-Jan | |
| article | 2019 | Comparing the Self‐Assembly of Sexiphenyl‐Dicarbonitrile on Graphite and Graphene on Cu(111) | Schmidt, Nico; Li, Jun; Gottardi, Stefano; Moreno-Lopez, Juan Carlos; Enache, Mihaela; Monjas, Leticia; van der Vlag, Ramon; Havenith, Remco W. A.; Hirsch, Anna; Stöhr, Meike | |
| article | 2019 | A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1 | van der Vlag, Ramon; Guo, Hao; Hapko, Uladzislau; Eleftheriadis, Nikolaos; Monjas, Leticia; Dekker, Frank J.; Hirsch, Anna | |
| article | 2019 | Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry | Prismawan, Deka; van der Vlag, Ramon; Guo, Hao; Dekker, Frank J.; Hirsch, Anna | |
| article | 2019 | Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol | Hartman, Alwin M.; Gierse, Robin M.; Hirsch, Anna | |
| article | 2019 | Energy-Coupling Factor Transporters as Novel Antimicrobial Targets | Bousis, Spyridon; Setyawati, Inda; Diamanti, Eleonora; Slotboom, Dirk J.; Hirsch, Anna | |
| article | 2019 | Reversible immobilization of a protein to a gold surface through multiple host-guest interactions | Schwarz, Dennis H.; Elgaher, Walid A. M.; Hollemeyer, Klaus; Hirsch, Anna; Wenz, Gerhard | |
| article | 2019 | Surface state tunable energy and mass renormalization from homothetic quantum dot arrays | Piquero-Zulaica, Ignacio; Li, Jun; Abd El-Fattah, Zakaria M.; Solianyk, Leonid; Gallardo, Iker; Monjas, Leticia; Hirsch, Anna; Arnau, Andres; Ortega, Enrique; Stöhr, Meike; Lobo-Checa, Jorge | |
| article | 2019 | Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling | Hollenhorst, Monika I.; Jurastow, Innokentij; Nandigama, Rajender; Appenzeller, Silke; Li, Lei; Vogel, Jörg; Wiederhold, Stephanie; Althaus, Mike; Empting, Martin; Altmüller, Janine; Hirsch, Anna K. H.; Flockerzi, Veit; Canning, Brendan J.; Saliba, Antoine-Emmanuel; Krasteva-Christ, Gabriela | |
| article | 2019 | Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics | Grandclaudon, Charlotte; Birudukota, N.V. Suryanarayana; Elgaher, Walid A.M.; Jumde, Ravindra P.; Yahiaoui, Samir; Arisetti, Nanaji; Hennessen, Fabienne; Hüttel, Stephan; Stadler, Marc; Herrmann, Jennifer; Miethke, Marcus; Hartmann, Rolf W.; Müller, Rolf; Hirsch, Anna K.H.; Brönstrup, Mark | |
| article | 2019 | Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination | van der Vlag, Ramon; Yagiz Unver, M.; Felicetti, Tommaso; Twarda-Clapa, Aleksandra; Kassim, Fatima; Ermis, Cagdas; Neochoritis, Constantinos G.; Musielak, Bogdan; Labuzek, Beata; Dömling, Alexander; Holak, Tad A.; Hirsch, Anna K. H. | |
| article | 2019 | Inverting Small Molecule-Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism | Bentler, Patrick; Bergander, Klaus; Daniliuc, Constantin G.; Mück-Lichtenfeld, Christian; Jumde, Ravindra P.; Hirsch, Anna K. H.; Gilmour, Ryan | |
| article | 2019 | Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity | Guo, Hao; Verhoek, Iris C.; Prins, Gerian G. H.; van der Vlag, Ramon; van der Wouden, Petra E.; van Merkerk, Ronald; Quax, Wim J.; Olinga, Peter; Hirsch, Anna K. H.; Dekker, Frank J. | |
| article | 2019 | Spray-drying of inhalable, multifunctional formulations for the treatment of biofilms formed in cystic fibrosis | Lababidi, Nashrawan; Ofosu Kissi, Eric; Elgaher, Walid A. M.; Sigal, Valentin; Haupenthal, Jörg; Schwarz, Bianca C.; Hirsch, Anna K. H.; Rades, Thomas; Schneider, Marc | |
| article | 2019 | Low-Dimensional Metal-Organic Coordination Structures on Graphene | Li, Jun; Solianyk, Leonid; Schmidt, Nico; Baker, Brian; Gottardi, Stefano; Moreno Lopez, Juan Carlos; Enache, Mihaela; Monjas, Leticia; van der Vlag, Ramon; Havenith, Remco W. A.; Hirsch, Anna K. H.; Stöhr, Meike | |
| article | 2019 | Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies | Della Volpe, Serena; Nasti, Rita; Queirolo, Michele; Unver, M. Yagiz; Jumde, Varsha K.; Dömling, Alexander; Vasile, Francesca; Potenza, Donatella; Ambrosio, Francesca Alessandra; Costa, Giosué; Alcaro, Stefano; Zucal, Chiara; Provenzani, Alessandro; Di Giacomo, Marcello; Rossi, Daniela; Hirsch, Anna K. H.; Collina, Simona | |
| article | 2019 | Concepts and Core Principles of Fragment-Based Drug Design | Kirsch, Philine; Hartman, Alwin M.; Hirsch, Anna K. H.; Empting, Martin | |
| article | 2018 | Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis | Unver, M. Yagiz; Gierse, Robin M.; Ritchie, Harry; Hirsch, Anna | |
| article | 2018 | Dynamic Proteoids Generated From Dipeptide-Based Monomers | Liu, Yun; Stuart, Marc C. A.; Buhler, Eric; Hirsch, Anna | |
| article | 2018 | Glucansucrase (mutant) enzymes from Lactobacillus reuteri 180 efficiently transglucosylate Stevia component rebaudioside A, resulting in a superior taste | Te Poele, Evelien M.; Devlamynck, Tim; Jäger, Manuel; Gerwig, Gerrit J.; Van de Walle, Davy; Dewettinck, Koen; Hirsch, Anna; Kamerling, Johannis P.; Soetaert, Wim; Dijkhuizen, Lubbert | |
| article | 2018 | Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin | Jumde, Varsha R.; Mondal, Milon; Gierse, Robin M.; Unver, M. Yagiz; Magari, Francesca; van Lier, Roos C. W.; Heine, Andreas; Klebe, Gerhard; Hirsch, Anna | |
| article | 2018 | Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments | Łozińska, Iwona; Świerczyńska, Aleksandra; Molęda, Zuzanna; Hartman, Alwin M.; Hirsch, Anna; Czarnocki, Zbigniew | |
| article | 2018 | Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor | Marcozzi, Alessio; Masini, Tiziana; Zhu, Di; Pesce, Diego; Illarionov, Boris; Fischer, Markus; Herrmann, Andreas; Hirsch, Anna | |
| article | 2018 | Delivery system for budesonide based on lipid-DNA | Liu, Yun; Bos, I. Sophie T.; Oenema, Tjitske A.; Meurs, Herman; Maarsingh, Harm; Hirsch, Anna | |
| article | 2018 | Exploration of ligand binding modes towards the identification of compounds targeting HuR : a combined STD-NMR and Molecular Modelling approach | Vasile, Francesca; Della Volpe, Serena; Ambrosio, Francesca Alessandra; Costa, Giosuè; Unver, M. Yagiz; Zucal, Chiara; Rossi, Daniela; Martino, Emanuela; Provenzani, Alessandro; Hirsch, Anna K. H.; Alcaro, Stefano; Potenza, Donatella; Collina, Simona | |
| magacineArticle | 2018 | Trendbericht Biochemie 2017: Proteinvermittelte dynamische kombinatorische Chemie | Hirsch, Anna K. H. | |
| article | 2017 | Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy | Wieczorek, Sebastian; Remmler, Dario; Masini, Tiziana; Kochovski, Zdravko; Hirsch, Anna; Börner, Hans G. | |
| article | 2017 | Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine | Monjas, Leticia; Swier, Lotteke J. Y. M.; Setyawati, Inda; Slotboom, Dirk J.; Hirsch, Anna | |
| article | 2017 | Saccharide-Containing Dynamic Proteoids | Liu, Yun; Stuart, Marc C. A.; Witte, Martin D.; Buhler, Eric; Hirsch, Anna | |
| article | 2017 | Lipid-DNAs as Solubilizers of mTHPC | Liu, Yun; de Vries, Jan Willem; Liu, Qing; Hartman, Alwin M.; Wieland, Gerhard D.; Wieczorek, Sebastian; Börner, Hans G.; Wiehe, Arno; Buhler, Eric; Stuart, Marc C. A.; Browne, Wesley R.; Herrmann, Andreas; Hirsch, Anna K. H. | |
https://orcid.org/0000-0001-8734-4663