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doi:10.22028/D291-28971
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Title: | A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion |
Author(s): | Guardado-Calvo, P Atkovska, K Jeffers, S A Grau, N Backovic, M Pérez-Vargas, J de Boer, S M Tortorici, M A Pehau-Arnaudet, G Lepault, J England, P Rottier, P J Bosch, B J Hub, Jochen Sebastian ![]() Rey, F A |
Language: | English |
In: | |
Title: | Science |
Volume: | 358 |
Issue: | 6363 |
Startpage: | 663 |
Endpage: | 667 |
Publisher/Platform: | American Association for the Advancement of Science (AAAS) |
Year of Publication: | 2017 |
Publikation type: | Journal Article |
Abstract: | The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe disease in humans and livestock across Africa. We determined the x-ray structure of the RVFV class II fusion protein Gc in its postfusion form and in complex with a glycerophospholipid (GPL) bound in a conserved cavity next to the fusion loop. Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring. The GPL head-group recognition pocket is conserved in the fusion proteins of other arthropod-borne viruses, such as Zika and chikungunya viruses, which have recently caused major epidemics worldwide. |
DOI of the first publication: | 10.1126/science.aal2712 |
Link to this record: | hdl:20.500.11880/27792 http://dx.doi.org/10.22028/D291-28971 |
ISSN: | 1095-9203 0036-8075 |
Date of registration: | 17-Sep-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Physik |
Professorship: | NT - Prof. Dr. Jochen Hub |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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