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doi:10.22028/D291-40002
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s41587-023-01751-6.pdf | 11,02 MB | Adobe PDF | View/Open |
Title: | Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues |
Author(s): | Wagner, Viktoria Kern, Fabian ![]() Hahn, Oliver Schaum, Nicholas Ludwig, Nicole Fehlmann, Tobias ![]() Engel, Annika Henn, Dominic Rishik, Shusruto ![]() Isakova, Alina Tan, Michelle Sit, Rene Neff, Norma Hart, Martin ![]() Meese, Eckart Quake, Steve Wyss-Coray, Tony Keller, Andreas ![]() |
Language: | English |
In: | |
Title: | Nature Biotechnology |
Publisher/Platform: | Springer Nature |
Year of Publication: | 2023 |
Free key words: | Ageing Computational biology and bioinformatics Diagnostic markers Geriatrics miRNAs |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Molecular mechanisms of organismal and cell aging remain incompletely understood. We, therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 organs at ten timepoints from 1 to 27 months) and rejuvenated mice. We found molecular aging trajectories are largely tissue-specifc except for eight broadly deregulated microRNAs (miRNAs). Their individual abundance mirrors their presence in circulating plasma and extracellular vesicles (EVs) whereas tissue-specifc ncRNAs were less present. For miR-29c-3p, we observe the largest correlation with aging in solid organs, plasma and EVs. In mice rejuvenated by heterochronic parabiosis, miR-29c-3p was the most prominent miRNA restored to similar levels found in young liver. miR-29c-3p targets the extracellular matrix and secretion pathways, known to be implicated in aging. We provide a map of organism-wide expression of ncRNAs with aging and rejuvenation and identify a set of broadly deregulated miRNAs, which may function as systemic regulators of aging via plasma and EVs. |
DOI of the first publication: | 10.1038/s41587-023-01751-6 |
URL of the first publication: | https://www.nature.com/articles/s41587-023-01751-6 |
Link to this record: | urn:nbn:de:bsz:291--ds-400026 hdl:20.500.11880/36014 http://dx.doi.org/10.22028/D291-40002 |
ISSN: | 1546-1696 1087-0156 |
Date of registration: | 21-Jun-2023 |
Description of the related object: | Supplementary information |
Related object: | https://static-content.springer.com/esm/art%3A10.1038%2Fs41587-023-01751-6/MediaObjects/41587_2023_1751_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41587-023-01751-6/MediaObjects/41587_2023_1751_MOESM2_ESM.xlsx |
Faculty: | M - Medizinische Fakultät |
Department: | M - Humangenetik M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professorship: | M - Univ.-Prof. Dr. Andreas Keller M - Prof. Dr. Eckart Meese |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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