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Titel: Dynamics of T cell subpopulations and plasma cytokines during the first year of antineoplastic therapy in patients with breast cancer: the BEGYN-1 study
VerfasserIn: Kaiser, Elisabeth
Weber, Regine
Hirschstein, Melanie
Mazid, Hala
Kapps, Emilie Marie Suzanne
Hans, Muriel Charlotte
Bous, Michelle
Goedicke-Fritz, Sybelle
Wagenpfeil, Gudrun
Zemlin, Michael
Solomayer, Erich-Franz
Müller, Carolin
Zemlin, Cosima
Sprache: Englisch
Titel: Breast Cancer Research
Bandnummer: 27
Heft: 1
Verlag/Plattform: BMC
Erscheinungsjahr: 2025
Freie Schlagwörter: Breast cancer
T cells
Cytokines
Chemotherapy
Endocrine therapy
Biomarkers
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background The role of T cell immunity during antineoplastic therapy is poorly understood. In the BEGYN-1 study, patients with breast cancer underwent quarterly assessments prior to and during antineoplastic therapy over a period of 12 months. Methods We used flow cytometry and multiplex immunoassays to quantify 25 T cell subpopulations and seven T cell associated plasma cytokines in peripheral blood from 92 non-metastatic breast cancer patients, respectively. In addition, the association between T cell dynamics and the outcome of patients undergoing neoadjuvant chemotherapy was investigated. Results In patients undergoing chemotherapy, a significant reduction in T helper (Th) cells, particularly naïve central and effector cells and thymus positive Th cells, was observed over time. Interestingly, Th1 immune responseassociated cytokines (IL-12, TNF, IFN-γ) declined while Th2 cells and cytotoxic T cells increased over time. Conclusions We conclude that in breast cancer patients, chemotherapy is associated with a transition from a Th1 immune response towards Th2 and an increase in cytotoxic T cells, whereas in patients without chemotherapy, these alterations were less pronounced. Future studies should clarify whether patterns of T cell subsets or plasma cytokines can be used as biomarkers to monitor or even improve therapeutic interventions.
DOI der Erstveröffentlichung: 10.1186/s13058-025-01997-9
URL der Erstveröffentlichung: https://doi.org/10.1186/s13058-025-01997-9
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-454581
hdl:20.500.11880/40045
http://dx.doi.org/10.22028/D291-45458
ISSN: 1465-542X
Datum des Eintrags: 27-Mai-2025
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Information
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Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Frauenheilkunde
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
M - Pädiatrie
Professur: M - Prof. Dr. E.-F. Solomayer
M - Prof. Dr. Stefan Wagenpfeil
M - Prof. Dr. Michael Zemlin
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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